Otava

Otava presents the new cAMP dependent protein kinase (PKA) focused library with 1998 compounds.

This library has been created as a part of a joint project aimed at design of a large set of receptor-based sharp-focused libraries. In the framework of this project, Life Chemicals provides its Collection of 300 000 compounds and subsequent chemical optimization. Otava provides its In-house Stock Collection (100 000 compounds) and also is responsible for molecular modeling tasks.
In mammalian cells, including human, ubiquitous enzymes known as protein kinase A (or PKA) regulate a huge number of processes, including growth, development, memory, metabolism, and gene expression. Failure to keep PKA under control can have disastrous consequences, including diseases such as cancer. The task of riding herd on PKA falls to cyclic adenosine monophosphate (cAMP), a messenger molecule involved in transmitting signals within the cell. Drugs based on inhibiting PKA activity are under development for treating disease, so understanding how cAMP accomplishes this task is of interest to life scientists.

Design of the focused libraries consists in Lipinsky/Veber rules filtering and flexible docking in a protein target of certain enzyme family. Further computational analysis for the presence of critical receptor-ligand hydrogen bond(s) and docking score refinement makes our focused libraries good starting point for drug discovery purposes.
The detection of H-bonding between ligand and key PKA residue (Val123) was used for the library preparation.
About Otava
Otava supplies Receptor Based and Target Focused compound libraries, custom synthesis, fine chemicals, ProHit compounds, protein kinase inhibitors, combinatorial chemistry templates and building blocks, fluorescent cyanine dyes, Noteworthy Compounds. They offer design and development of fluorescent probes, kits and reagents.
Company contact information:

OTAVA
P.O. Box 88
Kyiv 187, 03187
Ukraine
E-mails:
info**et**otavachemicals.com
mailotava**et**gmail.com

OTAVA – North American Division
15 Dundonald St., Suite 1902
Toronto, ON M4Y 1K4
Canada
Tel.: 1-416-305-9979
Fax: 1-866-881-9921 (Toll-free in US & Canada)
E-mail: north.america**et**otavachemicals.com