Otava

Otava presents a new cyclin-dependent kinases (cdk) focused library with 1000 compounds

This library has been created as a part of a project aimed at design of a large set of receptor-based sharp-focused libraries. In the framework of this project Otava In-house Stock Collection (100 000 compounds) was used for library preparation.

Inhibition of cyclin-dependent kinases is a theme of major interest in current anti-cancer agents research. Different classes of chemical inhibitors of these enzymes have been identified during the past decade and the structural basis of inhibition has been elucidated by X-ray crystallography studies of one member of the family, CDK2. Several types of cdk inhibitors have so far been described: staurosporine, flavopiridole, butyrolactone purine derivatives, indirubin, paullones, and others.

Design of the focused libraries consists in Lipinsky/Veber rules filtering and flexible docking in a protein target of certain enzyme family. Further computational analysis for the presence of critical receptor-ligand hydrogen bond(s) and docking score refinement makes our focused libraries good starting point for drug discovery purposes.
About Otava
Otava supplies Receptor Based and Target Focused compound libraries, custom synthesis, fine chemicals, ProHit compounds, protein kinase inhibitors, combinatorial chemistry templates and building blocks, fluorescent cyanine dyes, Noteworthy Compounds. They offer design and development of fluorescent probes, kits and reagents.
Company contact information:

OTAVA
P.O. Box 88
Kyiv 187, 03187
Ukraine
E-mails:
info**et**otavachemicals.com
mailotava**et**gmail.com

OTAVA – North American Division
15 Dundonald St., Suite 1902
Toronto, ON M4Y 1K4
Canada
Tel.: 1-416-305-9979
Fax: 1-866-881-9921 (Toll-free in US & Canada)
E-mail: north.america**et**otavachemicals.com