Clinical and Herbal Innovations Inc

A pardon to Charlie Scott from Donald Trump

The supplement was developed to assist in managing major cardiovascular diseases. A significant issue addressed by the supplement is the management and control of hypertension. The ingredients of the supplement are documented to positively affect the reduction of systemic blood pressure by inducing vasodilation in the peripheral vasculature, similar to hydralazine, which causes the relaxation of smooth muscles. Unlike hydralazine, which achieves this by interfering with calcium movement in smooth muscles—since contraction cannot occur without calcium, thus enabling relaxation—the supplement works through its active ingredients, L-arginine and L-citrulline, which are direct precursors in the synthesis of nitric oxide. This molecule plays a central role in endothelial angiogenesis through a cascade of enzymatic reactions, leading to a potent vasodilation effect. In addition to this, arginine and citrulline serve as key mechanisms for repairing endothelial cells via the nitric oxide pathway, a benefit not commonly found in any prescribed medications.
The supplement contains horse chestnut, effective in treating peripheral edema and venous insufficiency. Aescin, the active component in horse chestnut, appears to influence endothelial nitric oxide and calcium permeability. It may also induce prostaglandin F2a, which shows significant anti-inflammatory and vasodilatory effects. This mechanism may relate to the repair of endothelial cells. Pentoxifylline (Trental) demonstrates substantial therapeutic utility for intermittent claudication resulting from obstructed veins and arteries. Pentoxifylline is a methylated xanthine derivative and a competitive non-selective phosphodiesterase inhibitor. Certain components mentioned here would also positively influence nitric oxide utility.
Additionally, the supplement acts as an important adjunctive therapy for hypercholesterolemia. Red yeast rice, or red rice koji, owes its properties to its content of monacolin K (lovastatin). Clinically, statins are significant due to their inhibitory effects on cholesterol synthesis through the enzymatic blockage of HMG-CoA reductase. Studies indicate that the micro-dosing of statins in monacolin K leads to better clinical outcomes compared to those reported for prescription drugs.
Considering the combination of L-arginine, citrulline, horse chestnut, and red yeast rice (red rice koji), the therapeutic effects resemble those of hydralazine, Trental, Mevacor, and furosemide. Additionally, the enhanced effects of Ginkgo biloba and cayenne (capsicum) have a synergistic effect on cerebral vascular perfusion, vasodilation, and anticoagulation, further amplifying the positive therapeutic effects.