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AnaSpec, EGT Group

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AnaSpec Highlights MMP Inhibitors

San Jose, CA, May 25, 2011 --( AnaSpec, Eurogentec Group, is pleased to release 11 MMP inhibitors to complement their wide offering of MMP SensoLyte® 520 and 490 fluorimetric kits, colorimetric kits, recombinant proteins, and Z-Fish™ antibodies (antibodies specific for zebrafish). These MMP inhibitors are small molecules and act as either potent broad-spectrum inhibitors or selective inhibitors of MMPs. MMP inhibitors can be used as reference compounds for validating new MMP assays, and/or for identifying novel MMP inhibitors.

Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated zinc endopeptidases capable of digesting extracellular matrix components. 1,2 Many aspects of both physiological processes and pathological conditions are involved such as tumor development and metastasis, 3,4 rheumatoid arthritis. 5 As a result, compounds that inhibit MMP activity are considered promising therapeutic agents.6

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1. Woessner, JF. Jr. et al. J. Biol. Chem. 263, 16918 (1988).
2. Woessner, JF. Jr. FASEB J. 5, 2145 (1991).
3. Goldberg, GI. et al. Ann. N.Y. Acad. Sci. 580, 375 (1990).
4. Stetler-Stevenson, WG. et al. Ann. Rev. Cell Biol. 9, 541 (1993).
5. Gravallese, EM. et al. Arthritis Rheum. 34, 1076 (1991).
6. Levy, DE. et al. J Med Chem 41, 199 (1998).

AnaSpec, Eurogentec Group
AnaSpec, Eurogentec Group is a leading provider of integrated proteomics and genomics solutionsTM for worldwide life science research. AnaSpec offers expertise in peptides, detection reagents, antibodies, assay kits, amino acids, oligonucleotides, and qPCRs. AnaSpec carries a broad product line of biochemicals and reagents for basic research, high-throughput screening and drug discovery. AnaSpec also provides premier custom services including peptide synthesis, antibody production, assay development, fluorescent dyes, and oligonucleotide synthesis. AnaSpec is certified to ISO 9001:2008.

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AnaSpec, Inc.
Tiffany Kao

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