Business Directory, Press Releases, Jobs, Products, Services, Articles
Businesses Articles Press Releases Follow @PRcom
Press Release Pricing | News by Category | News by Country | News by US Region | Recent News | News on Your Site

Press Releases


Press Release

Receive press releases from GTCbio: By Email RSS Feeds:

Prof. Terry Hébert from McGill University to Present at GPCR in Drug Discovery Conference

Prof. Terry Hébert at McGill University, to talk on, "Assessing Bias and Allostery in GPCRs using Conformational Biosensors" at GPCR Meeting.

Monrovia, CA, August 27, 2016 --( Terry Hébert, Professor of Pharmacology and Therapeuticsat at McGill University, will give a presentation on, "Assessing Bias and Allostery in GPCRs using Conformational Biosensors" at GTCbio's 4th GPCR in Drug Discovery Conference to be held on September 14-15, 2016 in Boston, MA.

Ligand-biased signaling could have a significant impact on drug discovery programs in the pharmaceutical industry. As such, many investigators and screening campaigns are now being directed at a larger section of the signaling responses downstream of an individual G protein-coupled receptor. Biosensor-based platforms have been developed to capture signaling signatures. Despite the ability to use such signaling signatures, they may still be particular to an individual cell type and thus such platforms may not be portable from cell to cell, necessitating further cell-specific biosensor development. They have developed a complementary strategy based on capturing receptor-proximal conformational profiles using intra-molecular BRET-based sensors composed of a Renilla luciferase donor engineered into the carboxy-terminus and CCPGCC motifs which bind fluorescent hairpin arsenical dyes engineered into different positions in the AT1 angiotensin II receptor and the PGF2α receptor. Terry Hébert will discuss the design and optimization of such sensors to capture ligand bias and receptor dimerization-specific conformational crosstalk.

For more information, please visit website:
Contact Information
Kristen Starkey
635 W. Foothill Blvd.
Monrovia, CA 91016
Fax: 626-466-4433

Click here to view the list of recent Press Releases from GTCbio
Promote Your Business