Business Directory, Press Releases, Jobs, Products, Services, Articles
Businesses Articles Press Releases Follow @PRcom
Press Release Pricing | News by Category | News by Country | News by US Region | Recent News | News on Your Site

Press Releases

AnaSpec, EGT Group

Press Release

Receive press releases from AnaSpec, EGT Group: By Email RSS Feeds:

AnaSpec Introduces Two New IRAK1 Antibodies – pThr 209 & 387

AnaSpec has introduced two new phosphospecific IRAK1 polyclonal antibodies – anti-IRAK1 (pThr 209) and anti-IRAK1 (pThr387).

San Jose, CA, December 18, 2008 --( AnaSpec has introduced two new phosphospecific IRAK1 polyclonal antibodies – anti-IRAK1 (pThr 209) and anti-IRAK1 (pThr387). As seen on the dot blots (Figures 1-2), these antibodies are specific for the phosphothreonine sequence and not the non-phosphothreonine sequence. As well, the cross-reactivity between the pThr209 and pThr 387 antibodies is minimal (Figure 3).

Interleukin-1 (IL-1) receptor-associated kinase (IRAK) is a serine/threonine-specific kinase (1). The mammalian family of IRAK molecules contains four members (IRAK1, IRAK2, IRAK3/IRAK-M and IRAK4). The binding of IL-1 to IL-1 receptor type I (IL-1RI) initiates the formation of a complex that includes IL-1RI, AcP, MyD88 and IRAKs (2). IRAK undergoes autophosphorylation shortly after IL-1 stimulation and serves as a signaling molecule to mediate IL-1 response (3). IRAK mediates a signaling cascade leading to NF-KB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF) (1, 4).

Rabbit anti-IRAK-1(pThr209) – cat# 55331 polyclonal antibody was raised against a peptide corresponding to human IRAK1 at the phosphorylated threonine 209 (EISRGpTH), while Rabbit anti-IRAK-1(pThr387) – cat# 55333 polyclonal antibody corresponds to human IRAK1 at the phosphorylated threonine 387 (VRG-pTLAY). The non-phosphorylated version of these antibodies is also available. The IRAK1 antibodies have been evaluated for specificity by dot blot.


Dinarello, CA. Blood 87, 2095-2147 (1996).
Takaesu, G. et al. Mol. Cell. Biol. 21, 2475-2484 (2001).
Jianing H. et al. Proc. Natl. Acad. Sci. USA 94, 12829 (1997).
Robinson D. et al. Immunity 7, 571 (1997).

About AnaSpec

AnaSpec is a leading provider of integrated proteomics solutions to the world’s largest biotech, pharmaceutical, and academic research institutions. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents, and combinatorial chemistry.

For more information visit

Contact Information
AnaSpec, Inc.
Ping Yang

Click here to view the list of recent Press Releases from AnaSpec, EGT Group
Promote Your Business