AnaSpec Introduces New SensoLyte Anti-Human MOG (1-125) IgG ELISA Kit

San Jose, CA, May 03, 2009 --(PR.com)-- AnaSpec has announced the release of the newest addition to its Anti-MOG ELISA assay kit series – the SensoLyte Anti-Human MOG (1-125) IgG Quantitation ELISA Kit. This kit, along with previously featured SensoLyte Anti-Mouse MOG (1-125) and SensoLyte Anti-Rat MOG (1-125) IgG ELISA assay kits are useful for determining the amount of anti-human MOG (1-125), anti-mouse MOG (1-125) and anti-rat MOG (1-125) antibodies, respectively. These kits, as well as the recombinant MOG (1-125) proteins are examples of innovative products from AnaSpec.

MOG (1-125) is found in the extracellular domain of Myelin Oligodendrocyte Glycoprotein (MOG). MOG is a member of the immunoglobulin superfamily and is expressed exclusively in the central nervous system (CNS). Although MOG protein constitutes only 0.01-0.05% of the CNS myelin proteins, it is demonstrated that MOG protein is a crucial autoantigen for multiple sclerosis in humans and experimental autoimmune encephalomyelitis (EAE) in rodents and monkeys.1-6

SensoLyte Anti-Human MOG (1-125) Assay

SensoLyte Anti-Mouse MOG (1-125) Assay

SensoLyte Anti-Rat MOG (1-125) Assay

Specificity

Human

Mouse

Rat

Format

Human rMOG (1-125) precoated 12-strip plate

Mouse rMOG (1-125) precoated 12-strip plate

Rat rMOG (1-125) precoated 12-strip plate

Standard(s) Included

Mouse & Rat anti-human MOG (1-125) IgG standards

Anti-mouse MOG (1-125) IgG standard

Anti-rat MOG (1-125) IgG standard

Sensitivity

Detects as low as 1 ng anti-human MOG (1-125)

Detects as low as 1 ng anti-mouse MOG (1-125)

Detects as low as 1 ng anti-rat MOG (1-125)

Assay Time

2-3 hours assay time at room temperature

Sample Concentration

0.5-1 μl of serum or cerebrospinal fluid

Read-out

Colorimetric read-out at 450 nm absorbance

Broad Dynamic Range

8-500 ng antibody/ml serum (depending on colorimetric developing time)

References:

Linares, D. et.al. Protein Exp. Purif. 34, 249 (2004).
Bettadapura, J. et.al. J. Neurochem. 70, 1593 (1998).
Oliver, AR. et al J. Immunol. 171, 462 (2003).
Von Budingen, H. et.al. J. Clin. Immunol. 21, 155 (2001).
Lyons, J. et.al. Eur. J. Immunol. 29, 3432 (1999).
Von Budingen, H. et.al. Eur. J. Immunol. 34, 2072 (2004).

About AnaSpec
AnaSpec is a leading provider of integrated proteomics solutions to the world’s largest biotech, pharmaceutical, and academic research institutions. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents, and combinatorial chemistry.

For more information visit www.anaspec.com

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