CreAgri Reaffirms Its Commitment to Neuroprotection and Alzheimer’s Prevention in Light of German Research Project

Hayward, CA, March 29, 2015 --( Confirming its investment in the area of brain inflammation and neuroprotection, CreAgri welcomes German University of Darmstadt’s announcement on the launch of the research project NeurOliv with the support of the German government.

Directed at developing functional foods for patients with Alzheimer’s or just as way to protect and prevent the brain from aging, the NeurOliv consortium research leverages the anti-inflammatory and antioxidant activities of olive polyphenols, especially hydroxytyrosol.

In 2013, at the International Symposium on Functional Foods and Bioactive Compounds held at Kyoto’s Prefectural University, Hidrox®—CreAgri’s proprietary formulation of olive polyphenols—was proposed to support the management of neuroinflammation and other inflammation-based brain dysfunctions. Last summer, CreAgri cooperated with the University of California San Francisco and the University of Naples to sponsor an international scientific meeting on neuroprotection, "Biophysics of Amyloids and Prions," which took place in May 2014 at Naples' (Italy) Castel dell'Ovo.

The meeting featured the world’s 100 major researchers in the area of brain health, including Nobel Laureate Prof. Stanley B. Prusiner and small molecules design expert Dr. William De Grado. CreAgri delivered a keynote presentation by its CEO Dr. Roberto Crea on hydroxytyrosol and brain health.

CreAgri, Inc., a leader in the production of olive polyphenols for health and wellness, has been at the forefront of initiatives proposing the use of hydroxytyrosol to provide support to people affected by neurological dysfunctions since its first process discovery for the mass production of hydroxytyrosol from the juice of olives. Indeed, already in 2001 a small unpublished study conducted at the University of California San Francisco with patients suffering of HIV-induced dementia reported that hydroxytyrosol (Olivenol/Hidrox®) had an effect on cognitive activity. Hidrox® also showed significant anti-inflammatory activity in brain cells in an in vitro study carried out in collaboration with Sunnyvale's Parkinson's Institute, aimed at confirming Hidrox®'s ability to forestall neuroinflammation in a Parkinson's model.

More recently CreAgri's R&D in neuroprotective applications with Hidrox® have advanced at Mount Sinai Hospital's research collaboration supporting the use of Hidrox® to quench inflammation and to reduce oligomerization of tau proteins, as well as the formation of amyloid plaques. Similarly, an animal model study conducted by Boston-based Phylonix targeting the cytotoxicity of agents that can cause chronic demyelinating lesions similar to those present in multiple sclerosis confirmed the protective effect of Hidrox® against cuprizone-induced demyelization.

“Our commitment to develop further applications of Hidrox® in neuroprotection through collaborative efforts with premier research institutions is of primary importance; consumers and patients alike should expect new and powerful products for health and wellness directed at making their life healthier and more productive," declares Dr. Roberto Crea, founder and lead scientist in the discovery of the anti-inflammatory activity of hydroxytyrosol more than ten years ago.

"For more than 5 million of Americans and their families Alzheimer’s is a daily, devastating reality," adds Dr. Crea. "Current pharmacological solutions do not provide satisfactory outcomes; compounds such as Hidrox® may prove to be a natural and effective adjunctive tool in the options available to physicians today to manage this debilitating, mind-robbing condition. CreAgri's research confirms beyond doubts a role for Hidrox® and olive polyphenols in neuroprotection."

HIDROX® is CreAgri's trademarked hydroxytyrosol formulation, a powerful polyphenol scientifically recognized for its anti-inflammatory and antioxidant properties and efficacy in heart and joint health. GRAS certified, HIDROX® has been subjected to the most comprehensive set of clinical, safety and efficacy tests. HIDROX® is also covered by the largest number of international patents for applications that include hydroxytyrosol and olive polyphenol.

About CreAgri
CREAGRI® Inc., a California company, is the leading manufacturer of HIDROX® a proprietary hydroxytyrosol-rich ingredient. Its goal is to promote health and wellness by creating superior natural products that strike a balance between nature and technology. The Company develops science-based processes that are environmentally friendly and compatible with sustainable agricultural practices.

For media inquiries please contact Paolo Pontoniere,
VP - Corporate Communications, 510-732-6478
Creagri, Inc.
Paolo Pontoniere