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NuvOx Pharma

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NINDS Awards $150,000 Grant to NuvOx Pharma for Development of Field-Ready Syringe for Oxygen Delivery Drug


Tucson, AZ, December 30, 2017 --(PR.com)-- NuvOx Pharma, a clinical stage biotechnology company, has received a Phase I SBIR grant for $150,000 from the National Institutes of Health, specifically the National Institute of Neurological Diseases and Stroke (NINDS). This grant will fund development of a novel syringe sonication device that may allow quick preparation of an investigational drug for oxygen delivery.

The drug, NVX-208, is injected intravenously then travels through the bloodstream arriving first at the lungs to pick up oxygen and finally to hypoxic tissue where it delivers the oxygen. NVX-208 is more than half way through a Phase Ib/II clinical trial in patients with acute ischemic stroke. Animal studies in stroke have shown an 85% reduction in brain damage with NVX-208, and the drug has also shown efficacy in multiple animal models of traumatic brain injury and hemorrhagic shock. The drug currently has a shelf life of about 2 years under refrigerated storage, but this new invention may enable storage under a greater range of conditions. Evan Unger, MD, President and CEO of NuvOx Pharma, said, “Scientists at NuvOx discovered that application of ultrasound energy to pre-filled syringes with NVX-208 may be used to maintain the particle size within specification even under potentially extreme conditions. Successful completion of the project funded by NINDS could lead to development of a syringe enabling administration of the product for field based applications. Since earlier treatment could lead to better outcomes, administration of the drug in the pre-hospital setting or the battlefield could potentially improve outcomes in stroke, traumatic brain injury and blood loss.” NuvOx has filed a patent application for the syringe sonication device.

Kyle Morrison, President of Sonic Concepts, a company specializing in ultrasound technology, based in Bothell, Washington, added, “We are pleased to work with NuvOx on this project. Their drug has shown great promise to treat life-threatening acute conditions. Successful completion of this project should ultimately enable even earlier treatment in the field.”

NuvOx is a privately held company with clinical programs in brain cancer, stroke and sickle cell disease. For further information, please see www.nuvoxpharma.com or contact John McGonigle at jmcgonigle@nuvoxpharma.com.

Disclaimer: Certain statements in this release may constitute “forward-looking statements.” Actual events or results may differ substantially as a result of risks and uncertainties facing us. The forward-looking statements are based on current expectations as of the date of these statements. We undertake no obligation to publicly update or revise any forward-looking statements, whether as a result of future events, new information, or otherwise.
Contact Information
NuvOx Pharma
John McGonigle
(520) 624-6688
Contact
nuvoxpharma.com

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