San Jose, CA, December 22, 2019 --(PR.com
)-- Explore the new panel of anti-NF-kB and IkB antibodies from AbboMax. NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls the transcription of DNA. The larger NF-κB family of proteins is composed of two subfamilies: the ‘NF-κB’ proteins and the ‘Rel’ proteins. All of these proteins share a highly conserved DNA-binding/dimerization domain called the Rel homology domain (RHD). NF kappa B is a heterodimer consisting of a 50kDa DNA binding subunit and a 65kDa transactivating subunit. In unstimulated cells, this heterodimer is sequestered in the cytoplasm by p65 bound IKBα (Inhibitor of kBα).
In canonical activation pathway, in response to inflammatory mediators such as (but not only) tumor necrosis factor α (TNFα) and IL-1, IκB kinase (IKK) phosphorylates IκBα, leading to its ubiquitination and degradation, allowing NF-κB to translocate to the nucleus. NF-kB complex enters the nucleus where it can "turn on" the expression of specific genes that have DNA-binding sites for NF-kB. The activation of these genes by NF-kB then leads to the given physiological response, for example, an inflammatory or immune response, a cell survival response, or cellular proliferation. The NF-κB and IKK pathways do not exist in isolation and there are many mechanisms that integrate their activity with other cell-signalling networks.
NF-kB is present in almost all cell types. Disruption of NF-κB or IkB function contributes to many human diseases, including cancer. Active NF-κB turns on the expression of genes that keep a cell proliferating and protect a cell from apoptosis. Compared to normal, cancer cells exhibit aberrant constitutive NF-kB activation which is involved in multiple signaling cascades related to carcinogenesis, including survival, invasion and migration of cancer cells. It may happen either due to mutations in genes encoding the NF-κB transcription factors themselves, or in genes that control NF-κB activity (such as IκB genes), or some tumor cells secrete factors that cause NF-κB activation. Because NF-κB controls many genes involved in inflammation it is found to be chronically active in many inflammatory diseases.
Panel of NFkB related antibodies
IkBa(Paired S32/36) (NFKB1A)
AbboMax has been developing & manufacturing high performance immunoassay reagents for many years in California. The company specializes in high-quality custom service and products focusing on polyclonal, phosphospecific antibodies, IHC grade monoclonal antibodies, FFPE cell pellets slides, tissue/cell blocks and CRO services.